Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How You Will Achieve More At Intellia:
Are you a skilled and highly motivated Process Development Engineer II with AAV production experience in suspension systems at a 50L+ scale? Are you eager to join a talented team of professionals in a rapid growth genome-editing company with a drive to make a difference in patients’ lives? We are seeking a Process Development Engineer with leadership experience to support our AAV scale-up and non-GMP Production Teams. Activities support our internal process development team, our R&D and in vivo testing teams, and our Analytical Development department. This is an essential internal- and external-facing role within our Viral Vector Process Development team and collaborative Technical Operations organization as we advance our growing pipeline of ex vivo and in vivo gene therapies.
The position requires oversight of Intellia’s internal Vector Production Core, as well as optimization and scale-up of AAV production requiring a solid understanding of HEK293 cell growth and transfection in stirred-tank reactors, recovery unit operations and viral purification technologies as well as process-monitoring analytics. Key responsibilities include:
Support AAV process scale-up and optimization based on QbD for multiple AAV serotypes in transfection based processes;
Drug substance and drug product generation at 50L scale to support internal and CRO activities
Identify and define critical process parameters and support technology transfers to CDMOs and strategic partners working closely with process development and MSAT teams
Bachelor’s Degree in Biochemical Engineering, Molecular Biology, or Virology with at least 4 years of hands-on industrial experience, or MS with 2+ years of industry experience.
Experience in suspension cell culture transfection process scale-up, and stirred tank bioreactor operation, including perfusion systems; Normal Flow (depth filtration) and Tangential Flow Filtration (TFF) for Ultrafiltration/Diafiltration (UF/DF); chromatography-based purification with resins and other media.
Experience with Biologics Process Development, Technology Transfer to external CDMO, MSAT and/or Manufacturing in Cell & Gene technologies is required
Experience with viral vector analytics is a plus (e.g. CE-SDS, ddPCR, ELISA).
Meet your future team
In this role, you will be part of the AAV Process Development team, with key specialized functions. Our team of process engineers and process development professionals provide 1) small-scale vector core services for internal users 2) establish and optimize scale-up and to 50L process to tech transfer to external CDMOs 3) provide 50L-scale drug substance/ drug product supply for internal analytical and research needs. You will join the growing, collaborative and passionate Tech Ops team we advance our in vivo (VV) pipeline products using CRISPR genome-editing technologies.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.