Toxicology:
Associate Director of Molecular Pharmacology and Genotoxicity

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

Intellia is seeking an Associate Director of Molecular Pharmacology and Genotoxicity to support the advancement of genome editing products into the clinic.  Within this leadership role, you will contribute regulatory and practical considerations for genomic characterization strategy for in vivo and cell therapy programs.  This is a highly visible leadership position serving on multiple therapeutic program teams within Intellia and its partners, as well as interacting with health authorities.  In this role you will:

  • Serve as SME on program teams to advise on genomic characterization assessments in support of in vivo and cell therapy advancement to the clinic

  • Effectively interact with other functional area experts in a program team environment to recommend the best course of action for genomic assessments and defend those recommendations to internal governance committees and externally to health authorities

  • Inform and/or lead strategy for genome safety assessments for gene editing approaches including potential in silico, in vitro, and in vivo studies

  • Work closely with Genomic Innovation to align on genomic assays and workflows including laboratory experiments and bioinformatic analyses

  • Work closely with NGS production and PreClinical NGS for the execution of genomic data packages in support of regulatory filings and clinical programs

  • Partner with computational biology and software engineering on considerations for rigorous data capture, analysis, method qualification, and reporting Interact with Health Authorities, in writing and verbally, including pre-submission (e.g., pre-IND), scientific advice filings, IND or CTA, meeting briefing books, or other requests from global regulatory authorities

  • Serve as external SME for genome safety assessments for CRISPR based products presenting at conferences, interacting with NIST Genome Consortium, and supporting and writing manuscripts focused on genotoxicity methods and justification

About You:

The Associate Director of Molecular Pharmacology and Genotoxicity will have demonstrated expertise in NGS and other sequencing methodologies, molecular biology, gene editing approaches, experience in supporting gene editing therapies into the clinic including engaging with health authorities both written and verbally.

  • Ph.D. with 10 years directly related industry experience. 

  • Experience in writing and documentation to support regulatory filings as well as response to health authority questions and interacting with health authorities.

Meet your future team:

You will be an SME for genome safety and gene editing products working closely with Computational Biology, Pharmacology & Toxicology, Genomics Innovation, Genomics Operations, and PreClinical NGS to support the development of genome editing based therapeutics into the clinic.  We are accountable for enabling our programs in early research to reach development candidate nomination through regulatory filing and into clinical trials. In this key leadership role, you will report directly to the Senior Director, Pharmacology & Toxicology, who instills a culture of teamwork, respect, inclusion, collaboration, and communication ensuring that each team member strives to reach their professional and personal potential.

The team currently contains both hybrid and remote employees. While we don’t require you to be local to the Cambridge MA office, if local we do offer flexibility to work from home. Although in a partially virtual environment, the team has made it a priority to continue to foster a sense of community among the group. You can expect to join a passionate, hardworking, and collaborative environment.

Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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