Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How You Will Achieve More with Intellia:
Execute, develop, and optimize high throughput cell-based in vitro screening assay targeting deoxyribonucleic acid (DNA) endpoint sequencing. Characterize and quantify gene editing events for therapeutic drug discovery and its associated safety evaluation. Focus on high-throughput cell-based in vitro assays that utilize a variety of tissue- and cell-specific transfection-based methods that apply next generation sequencing (NGS) technologies, enabling massively parallel DNA sequencing to achieve the accuracy and sensitivity necessary to evaluate on-target editing events. Execute scientific experiments to produce data. Validate, optimize, automate and scale in vitro screening methods for the detection of CRISPR/Cas9 genome editing. Optimize, scale, and validate screening sequencing methods as well as to validate liquid-handling platforms and software in multi-step biological assays. Design, implement and troubleshoot experiments, both independently and in collaboration with colleagues to reach Intellia's desired goals. Operate sophisticated, expensive and sensitive liquid handling robotics including the Integra ViaFlow and the Hamilton MicroLab Star and massively parallel DNA sequencing machines requiring microfluidics. Provide support to guide RNA and messenger RNA chemistry platform as well as the lipid nanoparticle formulation platform by implementing in vitro assays to demonstrate potential therapeutic impact of various chemical and compositional modifications. Develop methods for insertion, excision and alternative nuclease gene editing programs. Any remaining time is spent on data analysis, interpretation and in meetings with key stakeholders to communicate data and further Intellia’s understanding and development of a broad class of CRISPR/Cas9 gene therapies. Conduct standard cell culture support. Analyze aligned sequencing data and synthesize conclusions to help with the identification of future directions.
Requires a Master’s degree in Biotechnology, Biological Sciences, or a directly related field plus two (2) years of laboratory experience in a cellular biology role involving the manipulation of cell-based systems.
Must have one (1) year of experience in the following (experience may be gained concurrently):
Laboratory experience in sterile technique and tissue culture of immortalized and primary cell lines
Experience with high-throughput liquid handling automation, including Hamilton and Integra
Experience operating and maintaining Illumina-based NGS platform technologies
Experience with nucleic acid purification and manipulation to create NGS libraries and preparation workflows, including polymerase chain reaction (PCR)
Experience with DNA or RNA quantification through quantitative real-time
Experience with Illumina next generation sequencing (NGS) equipment, including MiSeq, HiSeq, and NextSeq
Experience with immortalized and primary cell line culture and genetic perturbation through nucleic acid transfection or electroporation
Experience with DNA quantification through quantitative PCR reaction and single molecule digital droplet-based DNA quantification
Will accept a Bachelor’s degree plus five (5) years of experience in lieu of Master’s degree plus two (2) years of experience.
Position is fixed based in Cambridge, MA office; However, telecommuting from a home office location is allowed
Location: 40 Erie Street, Cambridge, MA 02139
Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.