Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
RESPONSIBILITIES:
Develop curative therapeutics using CRISPR/Cas9 technology for gene editing to achieve effective immunotherapy. Conduct in vivo and in vitro studies. Execute in vivo CRISPR screens to discover novel immunotherapy targets. Perform in vitro and in vivo cell lines characterization and validation of models and targets. Interrogate tumor microenvironments in different tumor models by dissecting the crosstalk between tumors and immune system and studying engineered T cell efficacy in various mouse models. Involved in experimental design, integrated data analysis and interpretations, and daily lab maintenance, including assisting in maintaining records for our vivarium and lab. These job responsibilities require various techniques and skill sets like mice handling, including bleeding, subcutaneous, intravenous, and intraperitoneal injections with tumor xenografts; monitoring excision, and necropsy; cell culturing, multi- color flow cytometry, cytokine profiling (MSD- ELISA), IVIS, western blotting, immune cell isolation, CFSE proliferation assay, T cell or NK cell activation/cytotoxic killing assays, and magnetic cell separation of CD4+/ CD8+ T cell transduction.
QUALIFICATIONS:
Requires a Master’s degree in Medical Biotechnology, Biotechnology, or a directly related field plus two (2) years of hands-on laboratory training experience.
Must have two (2) years of experience with each of the following (experience may be gained concurrently):
Experience with animal handling, breeding, tumor implanting, or measurement
Experience with multi-color flow cytometry to analyze T cell or tumor cells phenotypically and functionally
Hands-on experience with animal work, including animal imaging or breeding and i.p., i.v. and s.c. injection
Must have one (1) year of experience with each of the following (experience may be gained concurrently):
Using ELISA to analyze T cell functionally and assess the exhaustion status of T cells
Experience with cell culture to establish tumor models to dissect the crosstalk between tumor and immune system
Experience in laboratory techniques, including western blotting or RT-PCR
Experience with transfection and transduction
Evaluating engineered T cell efficacy in mouse models
Developing efficient and robust screening protocols
Planning and executing experience to drive hypothesis-driven in vivo and in vitro experiments
Telecommuting: Position is based in Cambridge, MA office; However, telecommuting from a home office may be allowed.
40 hours per week. Day shift. Send resume to: Deepanker.Goyal@intelliatx.com ref. P19.
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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.