Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How You Will Achieve More With Intellia:
The Associate Scientist is responsible for functions related to the genome editing of T cells for cell therapies using CRISPR/Cas9. Conceptualize, design, execute and troubleshoot experiments to knock out and insert genes within human T cells. Independently analyze results and optimize processes to drive towards higher editing efficiency and improved phenotype and viability. Perform in-vitro functional assays (cytotoxicity and cytokine release) to evaluate the anti-tumor potency of engineered T cells. Collaborate with others across a matrixed organization to improve understanding of the biology of CRISPR/engineering of T cells. Execute scientific experiments, produce data, validate and optimize protocols for CRISPR/Cas9 genome editing. Act as liaison with multiple teams in the ex-vivo emerging platform, ensuring alignment and support of T cell editing protocols for multiple programs. Analyze biological data and synthesize conclusions to help identify future directions of exploration. Maintain timely documentation of electronic lab notebooks and communicate /present data internally. Provide written reports to support regulatory and intellectual property filings.
Requires a Bachelor’s degree in Biological Sciences, Bioengineering, Medical Biotechnology, Pharmaceutical Sciences, or a directly related field plus five (5) years of industry laboratory experience. Candidates must have at least two (2) years of experience in each of the following (experience may be gained concurrently):
Experience with multi-color flow cytometry of T cells with up to 6 10 markers, including intracellular staining methods
Experience with in-vitro T cell assays, including cytokine quantification (ELISA or MSD) or cell-based cytotoxicity assays with tumor cell lines
Experience with human PBMC and T cell isolation, maintenance, electroporation, or viral transduction
Knowledge of the basic principles of cell biology and cell culture, including maintenance of primary cells in tissue culture using sterile technique, passaging of cell lines, cell counting and replating, troubleshooting of cell culture issues, and assessment of cell viability
In Addition, candidates must have at least one (1) year of experience in each of the following (experience may be gained concurrently):
Experience using CRISPR/Cas9 to edit genomes of primary human or mouse T cells
Diverse molecular biology techniques, including DNA and RNA quantification through quantitative real-time PCR and single molecule digital droplet PCR
Experience in high yield T-cell expansion using GREX or similar technology
Knowledge of Immunology, cell therapy, and the basics of gene editing
Knowledge of cell therapy landscape
Will accept a Master’s degree plus two (2) years of industry laboratory experience in lieu of Bachelor’s degree plus five (5) years of experience.
Meet Your Future Team:
This position is a fixed-location based in Cambridge, MA; However, telecommuting is occasionally allowed from a home-office location. This is a 40 hour per week, day-shift role.
Send resume to: David.Cicerone@intelliatx.com ref. P21.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.