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Research:
Associate Scientist, Pre-clinical Next Generation Sequencing
Our Mission: Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.
Job Description:
Intellia Therapeutics is seeking a highly motivated and skilled Associate Scientist to join our genomics team and support the characterization and quantitation of gene editing events using high throughput next generation sequencing (NGS).The successful candidate will be a part of the Screening and NGS Platform Development (SNPD) team, focused on pre-clinical NGS data support for IND packages. Applicants should have experience working in a high throughput environment and in executing NGS protocols in an SOP driven fashion. Familiarity with liquid handling robots and other automation systems is highly suggested. Experience in a clinical lab is a plus. Applicants should have exceptional time management and communication skills (both written and oral) coupled with a strong attention to detail.
Responsibilities:
- Support high throughput, SOP driven, NGS library preparation workflows both manually and using liquid handling automation
- Operate Illumina sequencing platforms
- Working with molecular biology techniques such as DNA purification, shearing, adapter ligation, PCR, NGS library purification and quantification
- Sample preparation techniques such as tissue homogenization and gDNA extraction
- Managing multiple workflow queues and requests
- Conduct experiments, troubleshoot and optimize, both independently and in collaboration with colleagues to meet deadlines
- Accurately document project and sample information, protocols, and experimental details through the Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN)
Qualifications:
- BS/MS in Molecular Biology or a related discipline with >5/>8 years of relevant experience in an academic or industrial setting.
- Experience with high throughput NGS library preparation workflows
- Experience and knowledge of molecular biology techniques
- Experience with cell culture and maintaining and plating a variety of immortalized and primary cell lines is a plus
- Experience with liquid handling platforms (preferably Hamilton) is a plus
- Proficient in troubleshooting NGS library preps
- Proficient in writing and following SOPs
- Excellent communication and attention to detail
- Strong time management and process-oriented thinking
- Must have the ability to work collaboratively and independently
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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.