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Development:
Principal Scientist, Cell Therapy Process Development
Our mission:
Developing curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.
Intellia is seeking a motivated Process Development candidate for a T cell Principal Scientist position to join our Cell Therapy Technical Operations team. The primary responsibilities for this position include driving platform development of allogeneic T cell therapy, focusing heavily on T cell selection. In addition, this position will require experience with leading process technology transfer to CDMO. As well, this position will involve collaborating with internal and external partners to form process characterization plans, process-related risk assessments, new technology evaluations, and manufacturing support. The ideal candidate has familiarity with both TCR and CAR-T related cell therapies.
Responsibilities:
- Lead development and optimization activities to establish a selection and enrichment platform for allogeneic T cell therapies, considering Quality by Design and closed systems.
- Evaluate and identify key performance parameters through hands-on process development pursuits.
- Establish a scalable allogeneic T cell process for gene editing using CRISPR tools and both non-viral and viral template delivery within a cross-functional team.
- Aid in technology transfer of allogeneic T cell process to CDMO, including review of protocols, MBRs, and reports, aligning with quality assurance expectations.
- Coordinate and/or participate in characterization of T cells during process development activities, partnering with analytical development.
- Directly supervise and provide training to junior process development team members, including experimental design oversight.
- Provide high quality data driven decision making within the CMC team and participate in strategic program discussions.
- Work effectively with independence and in collaboration with colleagues in support of program goals, communicating findings in a concise and timely manner.
Qualifications:
- PhD in Biochemistry, Biology, Biological Engineering, or Immunology with 5+ years hands-on experience, or master’s degree with 11+ years.
- Demonstration of aseptic cell culture, closed system process tools, and cryo-banking techniques are required. A candidate with CRISPR/gene editing experience would be preferred.
- Proficient in drafting Master Batch Records and Standard Operating Procedures for associated process equipment
- A thorough knowledge of immunology and experience with T cell receptor diversity.
- The ability to work effectively with management, process development, and supply chain to aid in sourcing reagents, evaluating multiple vendors to inform process decisions.
#LI-KO1
What Intellia Stands For:
We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:
- One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us – trusting and counting on every single one of us.
- Explore because we seek new ways to tackle disease. Explore with unbounded minds…free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.
- Disrupt by thinking courageously…and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts…with that breed of skepticism that shows you have better solutions.
- Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards…even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.
POSITION: Full-Time, Exempt
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Intellia’s web-based application process is managed through Lever. Information submitted through application forms is collected by Lever and subject to Lever’s privacy policy.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.