Nucleic Acid Therapeutics:
Senior Associate Scientist, Oligonucleotide Process Development

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How You Will Achieve More with Intellia:

We would be excited to welcome this new member to our growing team and company. This is a hands-on role in Oligonucleotide (sgRNA) process development for CRISPR/Cas 9 with the opportunity to support Intellia’s development pipeline for generating curative genome editing therapies. If you are a problem-solver, proactive, detail-oriented with synthetic oligonucleotides and genome editing or you already have a technical background in oligonucleotide synthesis and purification, this is the role for you! As a Senior Associate Scientist, you will be working with a cross-functional team (within Technical Operations) and support various activities including:

  • Setup of new oligonucleotide process development laboratory and supply chain
  • Perform solid-phase oligonucleotide syntheses to produce oligonucleotides at bench scale including downstream operations
  • Analyze the effectiveness of the synthesis (monitoring, in-process tests) and identify opportunities for process improvements to discuss with the team
  • Propose, plan and execute process development activities together with other team members
  • Creating report presentations and transfer documentation for external development
  • Adopt conditions from external manufacturers and internal research for feasibility assessments. Work cross-functionally with representatives of chemistry and analytical groups
  • Test and optimize downstream oligonucleotide processing including chromatographic purification methods
  • Act as a technical resource and author/review technical documentation such as SOPs, method documents, training documents, batch records and reports

This is a unique role that will provide you with opportunities to impact Intellia’s ex vivo and in vivo programs by:

  • Evaluating, establishing and developing syntheses and purification of sgRNA oligonucleotide sequences (CRISPR/Cas9)
  • Collaborate with Intellia’s cross-functional development team and optimize the manufacturing processes for the company’s development pipeline, which may include technical transfer to CMOs and interacting with external development teams

About You:

  • BS or MS in Chemistry, Biochemistry, Biotechnology or related field with 2 or more years of experience in an industrial setting with hands-on laboratory experience in relevant fields
  • Experience with solid-phase oligonucleotide synthesis
  • Chromatographic purification as well as general analytical techniques used for the analysis of DNA/RNA oligonucleotides is a plus

Meet Your Future Team:

The Oligonucleotide and Small Molecule Process Sciences Team is an experienced, highly-motivated, and lively group, with an innate curiosity that drives us to continue learning and making improvements. You will report to the Director of Nucleic Acid Therapeutics Development and Manufacturing (NTDM). The respective team is focused on various important activities with Technical Operations (CMC), including sgRNA and lipid manufacturing/process development. The team regularly interfaces via project teams and working groups with other CMC functions (Analytical Development, LNP process development, External Manufacturing/Supply Chain) as well as Quality and platform development. While a growing team of currently four team members, you will work closely with the broader NTDM team (approx. 25 individuals) as well as other groups within Technical Operations. Although we are currently working in a partially virtual environment, the Human Resources team and Cultural Ambassadors have made it a priority to continue to foster a sense of community among the group. This includes virtual happy hours, team all hands, game nights, and more! You can expect to join a hardworking, collaborative environment and to work with dedicated and team-spirited group of people.

Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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