This job opening is no longer active.
Nucleic Acid Therapeutics:
Senior Associate Scientist, Oligonucleotide Process Development

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

About Us:

At Intellia, we are revolutionizing medicine by harnessing the power of genome editing to develop CRISPR/Cas9 one-time treatments. We bring new hope for people living with severe and life-threatening conditions, such as cancer, genetic disorders, viral infections, inflammatory disorders and many more. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. Come see why we were voted one of the top places to work in 2021. 

How You Will Achieve More with Intellia:  

 

We are seeking an Associate/Senior Associate Scientist to join our growing process development group within our Tech Ops division. This a hands-on role in Oligonucleotide (sgRNA) process development for CRISPR/Cas 9 with the opportunity to support Intellia’s development pipeline for generating curative genome editing therapies. Under the direction of a senior scientist, you will perform a variety of research experiments including synthesis, deprotection, desalting, and purification of guide RNA. If you are a problem-solver, proactive, detail-oriented with curiosity to learn about synthetic oligonucleotides and genome editing or you already have a technical background in oligonucleotide synthesis and purification, this is the role for you! You will play a key role in advancing Intellia’s PD capabilities by: 

 

  • Performing amidite prep and solid phase oligonucleotide syntheses (AKTA Oligopilot) at bench scale.  

  • Develop and optimize downstream processes including ultrafiltration and purification of oligonucleotide products. 

  • Perform analysis of in-process tests (HPLC, UV-Vis) to evaluate process performance.  

  • Propose, plan, and execute process development activities together with other team members. Organize and present experimental data with internal and cross-functional teams. 

  • Aid in maintaining lab instruments such as AKTA synthesizers, purifiers, and HPLCs 

  • Adopt conditions from external manufacturers and internal research for feasibility assessments. Work cross-functionally with representatives of chemistry and analytical groups. 

  • Able to work independently in consultation with PD leadership and report status of assigned activities. 

  • Maintain electronic notebook, Lab SOPs, and chemical inventory. 

 

About You: 

  • BS or MS in Chemistry, Biochemistry, Biotechnology or related field with 2 or more years of experience in an industrial setting. 

  • Experience with solid-phase oligonucleotide synthesis, chromatographic purification as well as general analytical techniques used for the analysis of DNA/RNA oligonucleotides is a plus. 

 

 

Meet Your Future Team:  

 

The Oligonucleotide and Small Molecule Process Sciences Team is an experienced, highly motivated, and lively group, with an innate curiosity to learn and improve. The respective team is focused on various important activities with Technical Operations (CMC), including sgRNA and lipid manufacturing/process development. The team regularly interfaces via project teams and working groups with other CMC functions (Analytical Development, LNP process development, External Manufacturing/Supply Chain) as well as Quality and platform development. While a growing team of currently four team members, you will work closely with the broader NTDM team (approx. 25 individuals) as well as other groups within Technical Operations.  

 

Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.