AAV and Engineered T-Cells:
Senior Research Associate, AAV Process Development

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How You Will Achieve More At Intellia: 

Do you have experience in AAV vector production and are interested in an opportunity to bring AAV technology to a leading genome editing company using CRISPR-Cas9? Are you passionate about playing a key role in an internal, service-centric organization that is at the heart of the quality and speed of discovery efforts? This role supports company-wide research-grade AAV vector production for early discovery and small scale preclinical gene therapy studies for use across our in vivo and ex vivo product pipelines. The ideal candidate is a motivated self-starter with high scientific integrity ready to help build the Core into our next-gen offering and ready to tackle a diverse set of responsibilities in a team setting where collaboration, delivery, accuracy and quality are valued.  You should be highly motivated and passionate to work in a fast-paced and growing environment, and be a team player with an eye for continuous improvement. Key responsibilities include: 

  • Produce research-grade AAV vectors using suspension HEK293 system and bench-top AAVX loose resin affinity purification cell stacks, cell factories, small bioreactors 

  • Maintain seed train of production cell lines and inventory 

  • Coordinate production needs with different teams and manage supply chain and stakeholder communication 

  • Contribute to Core functions such as users requests dashboard and database maintenance, plasmids and AAV vector inventories, material and reagent supply, instrumentation maintenance, etc. 

  • Perform AAV analytics including ELISA and ddPCR to support in-process analytics in PD’s activities 

  • Proactively communicate risks to delivery to management 

  • Help establish and implement protocols, SOPs and systems within the developing team 

  • Seek opportunities for continuous improvement, waste reduction, operational excellence within the core 

About You: Do you have 2+ years of hands-on experience to produce research-grade AAV vectors within an AAV vector core required either in academic setting or industry (preferred) and are a well-organized and detail-oriented self-starter with a strong team-player mindset and ability to juggle multiple tasks and work in a fast-paced environment? Have you demonstrated excellent aseptic cell culture technique, including, transfection, development and maintenance of cell lines and their inventory all with high attention to detail, and possess the following? 

  • Bachelor’s degree required; Master’s degree preferred. 

  • Experience in high throughput AAV purification platforms, such as density gradient ultracentrifugation and loose resin affinity purification 

  • Good understanding of AAV analytics (ddPCR, ELISA, CE-SDS, AUC) in support of product characterization 

  • Ability to be proactive in managing stocking and inventory of supplies, reagents and consumables ordering 

  • Able to work independently or collaboratively with a high degree of drive and accountability within a team setting 

  • Excellent interpersonal skills and sharp verbal/written communication skills 

  • Be proficient in MS Office Arcspan, SmartSheets, Benchling is highly desirable 

  • Background and understanding of AAV biology as well as gene therapy are highly desirable 

Find your next long-term growth opportunity with us! 

Meet your future team 

In this role, you will be part of the AAV Production and Scale Up Core team reporting to the Core senior manager and play a key role in augmenting the Core service offerings. You will also be a part of the broader AAV Process Development organization. From this vantage point you will participate in and support multiple activities in the product development lifecycle, yet be a key member of a team accountable for R&D supply of AAV. You will join the growing, collaborative and passionate Tech Ops team as we advance our therapeutic pipeline products using CRISPR genome-editing technologies. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. 

Covid-19 Vaccination Policy: Effective Monday, January 3, 2022, all Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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