This role is open to current full-time students enrolled in a Masters program, set to graduate in May 2021.

We are looking for a Senior Research Associate that will provide assay and CRISPR reagent generation support. This will include providing cell culture and in vitro assay support; developing and running screens using libraries of CRISPR gene targeting reagents and performing weekly analysis and providing data results for screens and assays. 

GENERAL RESPONSIBILITIES: 

·      Provide cell culture, molecular biology, and in vitro assay support to assess T effector cell function 

·      Implement and troubleshoot experiments, both independently and in collaboration with colleagues, to reach desired goals 

·      Communicate research and development findings with internal and external partners 

·      Assist in maintaining general laboratory functionality 

·      Support development of new technologies and innovative approaches that aid in increased throughput 

REQUIRED SKILLS: 

·      Animal handling experience, including i.v., i.p. and/or s.c. injections 

·      Some experience with basic immunology assays such as immune cell isolation, multicolor flow cytometry, CFSE cell proliferation assays, T cell cytotoxic killing assays, ADCC assay, cytokine profiling assay by ELISA or MSD 

·      Experience with standard cellular biology techniques such as cell culture, freezing and thawing cells, etc. 

·      Familiarity with standard molecular biology and biochemical techniques, including PCR, DNA/RNA isolation, western blotting, etc. 

PREFERRED SKILLS: 

·      Experience with tumor monitoring, isolation and digestion, and TIL isolation highly preferred 

·      Familiarity with murine tumor models (genetically engineered or syngeneic) 

·      Gene editing experience 

·      Understanding of in vivo transplantation assays 

·      Experience with live animal surgical procedures and/or in vivo imaging 

·      Work with viral and non-viral delivery methods and lenti- or retroviral libraries a plus 

QUALIFICATIONS: 

·      M.S. in immunology, cell biology or related field with 0-2 years industry experience

·      Excellent interpersonal skills and ability to work efficiently and productively in a highly dynamic, scientifically rigorous and fast-paced environment 

COMPETENCIES: 

·      Attention to detail 

·      Ability to follow Standard Operating Procedures (SOPs) 

·      Exceptional time management 

·      Effective communication skills (both written and verbal) 

·      Ability to work independently and collaboratively