Nucleic Acid Therapeutics:
Senior Scientist

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How You Will Achieve More with Intellia:

We would be thrilled to welcome this new member to our growing team and company, as these are very exciting times of growth for Intellia. If you are a motivated problem-solver, detail-oriented and proactive, with an operational vision as well as hands-on experience in solid phase oligonucleotide synthesis and enjoy working in cross-functional teams, this is the role for you!

As process development scientist and SME supporting non-GMP and GMP manufacturing campaigns you will deconstruct manufacturing processes, analyze process data and evaluate process parameters (upstream/downstream) using scale down models in order to identify conditions that can be transferred internally or externally to ultimately inform Intellia’s GMP sgRNA manufacturing.

As a Senior Scientist, you should have experience working in an industry setting and understand the principles of GMP manufacturing. Your responsibilities may include:

  • Contribute to set up a new oligonucleotide (sgRNA) process development laboratory and establish supply chains, workflows and operation to model manufacturing processes.
  • Analyze processes and manufacturing data to inform, plan and execute process development activities.
  • Plan and execute process development studies (upstream/downstream) with the objective to introduce process improvements intro the GMP manufacturing of sgRNA. Support associated tech transfers.
  • Prepare and perform solid phase oligonucleotide syntheses (scale-down model) and purifications as well as associated in-process and final analytics as needed
  • Maintain instrumentation, create/document laboratory processes. Generate reports and other technical documents. Present context, data and finding to the team and cross functionally.
  • Strategize with cross-functional transition teams (research®development) and introduce new technologies to CMC workflows
  • Act as manufacturing SME for external mfg. campaigns and development projects interfacing with Intellia’s partnering CMOs and internal working groups (PM, EMSC, AD, QA/QC). Review process outlines, batch records and manufacturing data.
  • Access the literature, guidances for industry, databases, and technical documents to contribute to regulatory authoring and PD strategy.

About You:

  • PhD in Chemistry, Biochemistry, Biotechnology or related field with 2 or more years of experience in an industrial setting.
  • Hands-on experience with solid-phase oligonucleotide synthesis and competency in operation of lab-scale oligonucleotide synthesizers
  • Experience with chromatographic purification of oligonucleotides (MPLC and HPLC, e.g. IEX, IP-RP) as well as general analytical techniques used for the analysis of DNA/RNA oligonucleotides (UV/fluorescence spectroscopy, mass spectrometry, sequencing applications) is preferred.
  • Understanding of GMP manufacturing processes and experience interacting with CROs/CMOs are preferred.

Meet Your Future Team:

The Small Molecule Process Sciences Team (oligonucleotides, lipids and other small molecule entities) is a highly motivated and active group, with an innate curiosity to learn. The team is headed by Director of Nucleic Acid Therapeutics Development and Manufacturing (NTDM) and focuses on various activities with Technical Operations (CMC), including sgRNA and lipid manufacturing support, process development and tech transfer. The team interfaces via project teams and working groups with Analytical Development, LNP process development, External Manufacturing/Supply Chain as well as Quality and Transition Teams. While a growing team of currently four team members, you will work closely with the broader NTDM team (approx. 25 individuals) as well as other groups within Technical Operations.

Although Intellia currently is a partially virtual environment, the Human Resources team and Cultural Ambassadors have made it a priority to continue to foster a sense of community among the group. This includes virtual happy hours, team all hands, game nights, and more! You can expect to join a hardworking, collaborative environment and to work with dedicated and team-spirited group of people.

Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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