Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How You Will Achieve More with Intellia
Be the next Senior Scientist / Scientist to join our Analytical Development team! In this role, you will be will lead the development and execution of studies to characterize Intellia’s candidates by mass spectrometry to support product characterization, formulation development, process development, and manufacturing.
In this opportunity, your main responsibilities will include:
Functions independently as technical expert in mass spectrometry to develop, execute and troubleshoot experiments for LC-MS and LC-MS/MS based assays to assess in-process and drug product samples (e.g. Peptide mapping, intact molecular weight analysis, tandem MS analysis)
Quantify lipids and lipid nanoparticles using LC-MS/MS
Identify lipid degradation products and quantify them in drug substances
Support the development of new methods by identifying, evaluating and executing analytical methods to support ongoing analytical needs
Ability to implement MS or non-MS based methods to support regulatory and CMC
Participate in the support of analytical activities at CMOs and CTOs related to analytics including method qualification and validation, data trending, troubleshooting, optimization, review, and reporting
Assist in the execution of analytical development activities at CTOs and CMOs, including deliverables and timelines; participate in tech transfer of intellectual property, protocols/procedures, and know-how from internal labs to QC and CMOs/CTOs, or between CMOs/CTOs
Participate in BLA-enabling activities including product and process characterization, comparability studies, CQA assessment activities
Assist in review and writing of regulatory filings including IND/IMPD and BLA
Collaborate with process development, QA and QC functions to ensure strong cross functional collaborations and integrated process and product development and characterization
Ph.D. in chemistry, biology, biochemistry or related field and 4+ years of experience or Masters’ degree and 6+ years’ experience. Bachelor’s degree in chemistry, biology, biochemistry or related field and 8+ years’ experience in analytical development within a biotech/pharmaceutical analytical development and/or Quality Control environment required
Theoretical and hands-on knowledge and experience with mass spectrometry methods used for biopharmaceutical characterization and impurity identification including intact mass analysis, peptide mapping and impurity identification.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.