Job Openings

Technical Operations:
Senior Scientist, Small Molecule Oligonucleotide Process Development and Manufacturing

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How You Will Achieve More with Intellia:

We would be thrilled to welcome this new member to our growing team and company, as these are very exciting times for Intellia. As a process chemist and SME for process development and manufacturing, you will help manage CMOs, manufacturing campaigns, and drive process improvements to prepare for later stages of the development lifecycle. In addition to the primary responsibilities below, you'll also have the opportunity to gain hands-on experience in oligonucleotide process sciences.

  • Managing ongoing manufactures for proprietary lipids and small molecules while interfacing with the EMSC team, quality, and analytical development. This includes the review of technical updates to batch records, methods, and supporting documents, as well as evaluating and leveraging process data for decision making

  • Evaluating new partnership organizations, establishing, and maintaining relationships with CROs and CMOs

  • Analyze the feasibility of new syntheses and process steps and plan, drive process development projects, and evaluating of new technologies

  • Support impurity/degradant profiling and structural elucidation of impurities by NMR techniques. Build and test mechanistic hypotheses

  • Prepare and support regulatory filings and answering of questions from the regulators; author process change documentation, reports, SOPs as well as technical documentation

  • Act as organic chemistry SME for the oligonucleotide process development team to discuss mechanistic questions and guide decision making based on organic chemistry principles

  • Access the literature, regulatory guidances, databases, and technical documents to develop strategy, work plans, timelines in order to present data and findings to the larger group, cross-functional teams, and external partners

About You:

If you are an independent personal contributor and problem-solver, detail-oriented with an operational vision and a strong technical background in organic chemistry and with an interest in oligonucleotide synthesis, and enjoy working in cross-functional teams, this is the role for you! As a Senior Scientist, you should have initial experience working in an industry setting and managing relationships with CMOs/CROs. Additional requirements include:

  • Ph.D. in Chemistry or Biochemistry or related field with 3 or more years of experience in an industrial setting

  • Hands-on experience in organic synthesis, purification, and standard analytical techniques such as NMR structural elucidation and mass spectrometry

  • Competency in GMP manufacturing processes

  • An understanding of oligonucleotide solid-phase synthesis is preferred

Meet Your Future Team:

The Small Molecule Process Sciences Team (oligonucleotides, lipids, and other small molecule entities) is a highly motivated and lively group, with an innate curiosity to learn. You will report to the Director of Nucleic Acid Therapeutics Development and Manufacturing (NTDM). The respective team is focused on various important activities with Technical Operations (CMC), including sgRNA and lipid manufacturing/process development. The team regularly interfaces via project teams and working groups with other CMC functions (Analytical Development, LNP process development, External Manufacturing/Supply Chain) as well as Quality and platform development. While a growing team of currently three team members, you will work closely with the broader NTDM team (approx. 20 individuals) as well as other groups within Technical Operations.

Although Intellia currently is a partially virtual environment, the Human Resources team and Cultural Ambassadors have made it a priority to continue to foster a sense of community among the group. This includes virtual happy hours, team all-hands meetings, game nights, and more! You can expect to join a hardworking, collaborative environment and to work with a dedicated and team-spirited group of people.

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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