Open Positions

Senior Scientist – RNA Chemistry

SUMMARY:

Intellia Therapeutics is seeking an experienced Senior Scientist to join the RNA Chemistry Team, which is responsible for the production of synthetic oligonucleotides. This individual will be involved in a complete production process for the identification, implementation & fulfillment of synthesis, purification and reaction scheme analytical characterization and method development of oligonucleotides.

RESPONSIBILITIES:

• Be the key go-to person with strong hands-on experience and detailed knowledge of oligonucleotides. sgRNA synthesis experience is preferred.
• Independently handling automated oligo synthesis using solid phase eg. OP10, OP100 (preferred) and take responsibility to trouble shoot in case of challenges.
• Independently handle the Akta- purification systems and TFF processes.
• Tech transfer from lab to plant using sound process engineering principles of oligonucleotides, phosphoramidites, nucleic acid synthesis.
• Optimization and scale up of oligonucleotide (Solid phase synthesis) processing method from Lab scale to manufacturing scale.
• Interpretation of HPLC/LCMS analysis of oligonucleotides (ESI, MALDI-TOF, Orbitrap, APCI, Q-TOF, MS/MS etc.)
• Process engineering troubleshooting, data interpretation using advance software for oligonucleotides.
• Focus on deliverable of project right from Initiation to end.
• Manage and develop team through scientific learning and development for oligonucleotides.
• Communicate seamlessly with the stake holder and provide them the necessary data, take inputs and drive the project to stake holder satisfaction.
• Ability to work with leadership and management team.
• Experience using QbD principles for process development and optimization method troubleshooting skills as well as knowledge of various data analysis.
• Strong technical problem-solving ability and act as SME for OP100 and Mermade synthesizer.
• Develop and validate robust scientifically advanced methods with the required performances attributes to satisfy stakeholder needs.
• Write and follow standard operating procedures.
• Ensure safety and product quality are paramount throughout the laboratory environment.

QUALIFICATIONS:

Ph.D. in Chemistry, Organic Chemistry, Nucleoside Chemistry related discipline with minimum 2 years’ experience, preferably in oligonucleotide field.

Basic computer skills including MS Office Suite.

TECHNICAL /FUNCTIONAL SKILL:

• Having sound knowledge and hands on experience in protecting/deprotecting group chemistry of nucleosides/nucleotides, phosphoramidites, oligonucleotides etc.
• Sound knowledge of oligonucleotide eg. amidite coupling, detritylation, oxidation, thiolation etc. using solid phase/solution phase synthesis.
• Sound knowledge of cleavage and deprotection conditions, purification, lyophilization etc. for oligonucleotides/peptides.
• Strong experience in working with wide ranging oligo reagents eg. activators, deblocking agents, thiolating/oxidizing reagents, capping reagents, solid support resins etc.
• Good exposure to various oligonucleotides such as sgRNA, siRNA, antisense, miRNA, aptamers, branching oligonucleotides, oligonucleotide-conjugates
• Good working knowledge and experience in handling preparative or buffer based HPLC/LPLC.
• Adequate knowledge of analytical techniques like HPLC, UPLC, GPC etc. for oligonucleotide.
• Good organizational skills and hands on experience.
• Excellent in computational skills using various software eg. Unicorn, for synthetic oligonucleotides.
• In-depth knowledge of cGMP or cGXP in oligonucleotides as well as root cause analysis technique.
• Ability to work in an industrial set-up involving cross-functional teams from QC, QA, production etc. in synthetic large molecule area.
• Excellent technical writing and documentation skills.
• Excellent communication skills and capable of interacting with multiple stake holders.

COMPETENCIES:

Attention to detail

Exceptional time management

Effective communicator

Capable of repetitive tasks and performing other duties as assigned

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its current and future employees. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law

Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.