David Lebwohl, M.D.
Executive Vice President, Chief Medical Officer
Dr. David Lebwohl’s career spans three decades in the biopharmaceutical industry, successfully bringing novel medicines through all phases of clinical trials and global regulatory approvals. During his career, he has overseen multiple full-scale development programs with more than 200 clinical studies across myriad indications.
Before Intellia, David was chief medical officer at Semma, Therapeutics Inc., a subsidiary of Vertex Pharmaceuticals Inc., where he was leading the company’s regenerative medicineUsing a combination of tissue engineering and molecular biology to treat genes – the root causes of gene-based diseases and disorders. This new field brings together biology, chemistry, computer science, engineering, genetics, medicine, robotics and other fields to find the solution to some of the most challenging health issues in medicine. efforts using stem-cell-derived pancreatic islets to cure type I diabetes. Prior to his role at Semma Therapeutics, David held numerous senior-level positions leading drug development at the global healthcare company, Novartis Pharmaceuticals Inc. There, he was most recently senior vice president and franchise global program head, CAR-TCAR-T cell stands for chimeric antigen receptor (CAR) T cell therapy. This therapy type modifies immune cells (T cells) to express a receptor on their surface that recognizes and binds to molecules (antigens) on the surface of malignant or cancerous cells. Once the receptor binds to a tumor antigen, the T cell is activated to attack the malignant cells., Promacta and SEG101 Global Program Teams, responsible for the development of the breakthrough therapy Kymriah® (tisagenlecleucel), approved for the treatment of B-cell acute lymphoblastic leukemia and diffuse large B cell lymphoma. During his time at Novartis, David was responsible for numerous oncology drug development programs. Under his leadership, the blockbuster drug, Afinitor® (everolimus), was approved for five indications, including metastatic breast, neuroendocrine and kidney cancer and a rare genetic disease, tuberous sclerosis. Prior to working at Novartis, David spent five years at Bristol Myers Squibb Inc., where he led oncology development teams at the company’s Pharmaceutical Research Institute.
He is a well-recognized medical oncologist, with certifications in hematology and internal medicine. David received an undergraduate degree in Biochemical Sciences from Harvard College and an M.D. from the Yale University School of Medicine. He completed his fellowship training at Memorial Sloan Kettering Cancer Center and his residency in Internal Medicine at Brigham and Women’s Hospital in Boston. David has authored more than 50 peer-reviewed publications and is a member of the American Society of Clinical Oncology.