Bo Han

On Intellia’s culture

At Intellia, the executives care about everybody’s voice, so every one of us can make a difference. Also, I’m given enough time and freedom to learn novel technologies and apply them to my work.

On Intellia’s science

I’m confident that the work Intellia does will change human lives dramatically in the near future. It’s very exciting to be part of it. Genome editingAlso called gene editing. Genome editing collectively refers to a set of technologies, including CRISPR/Cas9, that can be used to cut and modify DNA. Genome editing uses systems to make the DNA change inside the cell. These cells can be edited in the body (in vivo) or outside the body (ex vivo) from a patient or donor. is highly complex. Some edits work; others don’t. We are finding out what makes one better than another and the contribution each one makes. All this can be described and predicted in a quantitative way.

On a personal note

My work has greatly changed the way experimental scientists do their daily work at Intellia. Some of the stuff I built enables them do things hundreds of times faster. That is so satisfying.

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On Intellia’s culture

The company has an aura of energy and excitement that I felt the minute I walked in the door. The culture at Intellia is one of inclusion and collaboration. Everyone has a voice that is heard and valued. I can see and feel the impact that I am having on the success of the company. We are all very passionate about what we do, but no one takes themselves too seriously. I have had a tremendous amount of growth in my career during my time at Intellia. I highly value the company’s commitment to career growth and development and making sure that employees feel valued.

On Intellia’s science

I could not pass up the opportunity to work on such ground-breaking science. The technology is extremely exciting and moving at a pace that I have never experienced before.

On a personal note

Intellia’s mission is to create and deliver medicines. If I can help fulfil that, I have exceeded my mission. Good friends of mine have a son diagnosed at the age of two with a life-threatening condition. I know we can use our technology to create a treatment.

On Intellia’s culture

Our group values teamwork and high quality science… reasons I’m proud to be a part of it. We celebrate our successes… mostly with lots of dancing in the lab!

On Intellia’s science

Genome editingAlso called gene editing. Genome editing collectively refers to a set of technologies, including CRISPR/Cas9, that can be used to cut and modify DNA. Genome editing uses systems to make the DNA change inside the cell. These cells can be edited in the body (in vivo) or outside the body (ex vivo) from a patient or donor. is the hottest technology in science. The ability to deliver a therapy in a single administration and potentially be curative is game-changing.

On a personal note

I hope to improve healthcare for the next generation. Exciting and disruptive science and great people – those are the most compelling reasons to work here.

On Intellia’s culture

Three words sum up the culture here: fun; fast; energetic. The work is interesting, there’s constant variety, and great people. Because the company is growing, there’s lots of room for creativity, responsibility and exciting work, regardless of your position. We collaborate, share responsibilities and look out for each other.

On Intellia’s science

I want to live and work in a way that makes a positive impact on the lives of people around and that parallels the therapeutic mission of the company. Our platform has high potential to change patients’ lives, and Intellia has the expertise to turn the technology into a therapeutic reality.

On a personal note

I’m a scientist by training and became an attorney focused on intellectual property. I joined Intellia to learn more broadly and contribute to building a successful business. The best parts are my team and the friends I’ve made here.

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On Intellia’s culture

People at Intellia are very motivated, collaborative and working towards the common goal of developing potentially curative genome editingAlso called gene editing. Genome editing collectively refers to a set of technologies, including CRISPR/Cas9, that can be used to cut and modify DNA. Genome editing uses systems to make the DNA change inside the cell. These cells can be edited in the body (in vivo) or outside the body (ex vivo) from a patient or donor. treatments.

On Intellia’s science

CRISPR/Cas9Adapted from a naturally occurring bacterial immune system, CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. One of the proteins in the CRISPR system is known as CRISPR-associated 9 protein or Cas9 protein, which acts as a pair of ‘molecular scissors’ to cleave DNA. Researchers have co-opted the bacterial CRISPR/Cas9 system to make specific changes in the DNA of humans, other animals and plants. CRISPR/Cas9 was first harnessed in 2012 as a genome editing tool in the lab. More recently, scientists have begun engineering and testing CRISPR systems to be very specific to a desired genetic target. therapeutics is a cutting-edge technology that can positively transform the lives of people living with severe and life-threatening diseases.

On a personal note

For most part of my career, I have worked on RNAi delivery and have seen its translation from bench to the clinic. I feel excited to be part of Intellia, where I am working on the translation of CRISPR technology from the bench to the clinic as well.

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