Overview
One of Intellia’s co-founders, Jennifer Doudna, along with Emmanuelle Charpentier, was awarded the 2020 Nobel Prize in Chemistry for their pioneering work in CRISPRAdapted from a naturally occurring bacterial immune system, CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. One of the proteins in the CRISPR system is known as CRISPR-associated 9 protein or Cas9 protein, which cleaves the DNA. Researchers have co-opted the bacterial CRISPR system to make specific changes in the DNA of humans, other animals and plants. CRISPR was first harnessed in 2012 as a genome editing tool in the lab. More recently, scientists have begun engineering and testing CRISPR systems to be very specific to a desired genetic target.. Intellia’s researchers work tirelessly to harness CRISPR gene editingAlso called genome editing. Gene editing collectively refers to a set of technologies, including CRISPR/Cas9, which can be used to cut and modify DNA. Gene editing uses systems to make the DNA change inside the cell. These cells can be edited in the body (in vivo) or outside the body (ex vivo) from a patient or donor. and other core technologies for human therapeutic use.
At Intellia, we are humbled to have a hand in making what we believe to be medical history. As a leader in the space, our responsibility and commitment to patients is critical as we pursue the development of novel, potentially curative treatments.
We are employing our proprietary technologies to create diverse therapeutic approaches spanning a range of diseases to realize Intellia’s full potential and address the needs of patients globally.
Our Mission
To transform the lives of people with severe diseases by developing and commercializing potentially curative treatments.
Strategy
Advance our lead product candidates
Complete late-stage development of Intellia’s in vivoMeaning “within the living,” this type of therapy is administered directly into the patient, targeting the cells and editing the genome from inside the body. CRISPR-based product candidates for hereditary angioedemaAlso known as HAE. Rare and potentially life-threatening genetic disease characterized by overproduction of bradykinin, which leads to recurring, severe and unpredictable swelling in various parts of the body. and ATTRAlso known as ATTR amyloidosis. A rare genetic disease caused by accumulation of misfolded transthyretin (TTR) protein, which affects the nerves, heart, kidneys and eyes. Patients can develop amyloidosis by inheriting the faulty TTR gene from a parent (hereditary ATTR amyloidosis, ATTRv or hATTR) or due to a natural form of this protein, without genetic mutation (wild-type ATTR amyloidosis, ATTRwt or wtATTR). amyloidosis
Build a fully integrated commercial infrastructure
Become a self-sustaining biopharmaceutical company with capabilities from drug discovery through commercialization
Expand pipeline to new indications
Build on Intellia’s initial scientific success by developing additional product candidates leveraging our proprietary technologies
Collaborate with
partners
Maintain strategic partnerships to expand our technology reach and address additional unmet needs for patients globally
Core Values
Our values are at the heart of our company’s identity and culture.
Management Team
Our leaders bring all the necessary skills and experience from world-leading organizations and embody Intellia’s values — one, explore, disrupt, deliver — to deliver new therapeutics that durably treat the root causes of disease. Our team comprises experts in all aspects of developing and commercialization of human therapeutics, including preclinical research, manufacturing and clinical development.
John Leonard, M.D.
James Basta, J.D.
Eliana Clark, Ph.D.
Chief Technical Officer
Edward Dulac
Chief Financial Officer
David Lebwohl, M.D.
Chief Medical Officer
Birgit Schultes, Ph.D.
Chief Scientific Officer
Maria Natale
Commercial
Marika St. Amand
Chief Human Resources Officer
Board of Directors
Industry veterans and experienced investors with demonstrated skills in building leading biotechnology companies.
Frank Verwiel, M.D.
Muna Bhanji, R.Ph.
Bill Chase
Fred Cohen, M.D., D.Phil, F.A.C.P.
Brian Goff
Jesse Goodman, M.D.
Georgia Keresty, Ph.D., M.P.H.
John Leonard, M.D.
Partnering
We are proud to partner with organizations that share our determination to revolutionize medical science.
We believe collaborations will play a critical role in expanding the commercial potential of our product candidates, powering the development and deployment of our technology and benefitting our stakeholders, including patients and the healthcare system. We also scout cutting-edge technologies that may advance the application of our core technologies.