About
We are employing our proprietary technologies to create diverse therapeutic approaches spanning a range of diseases to realize Intellia’s full potential and address the needs of patients globally.
One of Intellia’s co-founders, Jennifer Doudna, along with Emmanuelle Charpentier, was awarded the 2020 Nobel Prize in Chemistry for their pioneering work in CRISPRAdapted from a naturally occurring bacterial immune system, CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. One of the proteins in the CRISPR system is known as CRISPR-associated 9 protein or Cas9 protein, which cleaves the DNA. Researchers have co-opted the bacterial CRISPR system to make specific changes in the DNA of humans, other animals and plants. CRISPR was first harnessed in 2012 as a genome editing tool in the lab. More recently, scientists have begun engineering and testing CRISPR systems to be very specific to a desired genetic target.. Intellia’s researchers work tirelessly to harness CRISPR gene editingAlso called genome editing. Gene editing collectively refers to a set of technologies, including CRISPR/Cas9, which can be used to cut and modify DNA. Gene editing uses systems to make the DNA change inside the cell. These cells can be edited in the body (in vivo) or outside the body (ex vivo) from a patient or donor. and other core technologies for human therapeutic use.
Our Pipeline
To transform the lives of people with severe diseases by developing and commercializing potentially curative treatments.
Our strategy for developing and commercializing potentially curative treatments.
At Intellia, we are humbled to have a hand in making what we believe to be medical history. As a leader in the space, our responsibility and commitment to patients is critical as we pursue the development of novel, potentially curative treatments.
Advance our lead product candidates
Complete late-stage development of Intellia’s in vivoMeaning “within the living,” this type of therapy is administered directly into the patient, targeting the cells and editing the genome from inside the body. CRISPR-based product candidates for hereditary angioedema and ATTRAlso known as ATTR amyloidosis. A rare genetic disease caused by accumulation of misfolded transthyretin (TTR) protein, which affects the nerves, heart, kidneys and eyes. Patients can develop amyloidosis by inheriting the faulty TTR gene from a parent (hereditary ATTR amyloidosis, ATTRv or hATTR) or due to a natural form of this protein, without genetic mutation (wild-type ATTR amyloidosis, ATTRwt or wtATTR). amyloidosis
Build a fully integrated commercial infrastructure
Become a self-sustaining biopharmaceutical company with capabilities from drug discovery through commercialization
Expand pipeline to new indications
Build on Intellia’s initial scientific success by developing additional product candidates leveraging our proprietary technologies
Collaborate with partners
Maintain strategic partnerships to expand our technology reach and address additional unmet needs for patients globally
Our values are at the heart of our company’s identity and culture.
One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us – trusting and counting on every single one of us.
Explore because we seek new ways to tackle disease. Explore with unbounded minds… free from assumptions, open to ideas. Explore by staying curious and pushing boundaries. Explore means thinking of new ways to overcome obstacles.
Disrupt by thinking courageously… and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts, and using skepticism and imagination to develop new ways, innovative solutions.
Deliver by focusing on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards… even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise a reality. Get it done.
Management Team
Our leaders bring all the necessary skills and experience from world-leading organizations and embody Intellia’s values — one, explore, disrupt, deliver — to deliver new therapeutics that durably treat the root causes of disease. Our team comprises experts in all aspects of developing and commercialization of human therapeutics, including preclinical research, manufacturing and clinical development.
Board of Directors
Industry veterans and experienced investors with demonstrated skills in building leading biotechnology companies.
Partnering
We are proud to partner with organizations that share our determination to revolutionize medical science.
We believe collaborations will play a critical role in expanding the commercial potential of our product candidates, powering the development and deployment of our technology and benefitting our stakeholders, including patients and the healthcare system. We also scout cutting-edge technologies that may advance the application of our core technologies.
Regeneron
Regeneron is a leading biotechnology company that invents, develops and commercializes life-transforming medicines for people with serious diseases.
Intellia and Regeneron entered into a license and collaboration agreement to research, develop and potentially commercialize CRISPR/Cas9-based therapeutic products focused on genome editing in the liver. In addition, Intellia and Regeneron continue to collaborate on the development and commercialization of an investigational product for ATTR amyloidosis, as well as several other programs.
AvenCell
AvenCell’s mission is to develop next-generation immunotherapies for difficult to treat cancers using its clinical-stage universal CAR-T platform with Intellia’s differentiated allogeneic cell engineering platform.
AvenCell was launched by Intellia, Blackstone Life Sciences, Cellex Cell Professionals GmbH and GEMoaB, now named AvenCell Europe GmbH. View Press Release
Kyverna
Kyverna Therapeutics is a cell therapy company with the mission of engineering a new class of therapies for autoimmune and inflammatory diseases.
Intellia and Kyverna entered into a licensing and collaboration agreement for the development of an allogeneic CD19 CAR-T cell therapy for the treatment of various B-cell-mediated autoimmune diseases. View Press Release