Bradykinin
A peptide released from the biological pathway involving the KLKB1 gene and kallikrein activity. A reduction of kallikrein activity achieved through knockout of the KLKB1 gene is expected to correlate with a decrease in bradykinin activity. In turn, this decrease in bradykinin activity is expected to prevent the activation of endothelial cells that causes vascular leakage and angioedema in HAE patients.
