A CRISPR Moment in Time
A CRISPR Moment in Time

When I graduated medical school in 1983, if someone had asked me then, “What do you think the medical field will look like in 40 years?” I couldn’t have imagined the possibility of where we are today. The idea of editing DNA to possibly treat someone of a rare, genetic disease would have seemed unreachable.

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Marking Milestones, the CRISPR Way
Marking Milestones, the CRISPR Way

Today we celebrate a game-changing tool in research and medicine. Ten years ago, one of Intellia’s founders, Dr. Jennifer Doudna, and her collaborator, Dr. Emmanuelle Charpentier, published a paper in Science, detailing the power of CRISPR/Cas9 to edit strands of DNA at precise locations.

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Assembling Intellia’s Full-Spectrum Toolbox
Assembling Intellia’s Full-Spectrum Toolbox

Being full spectrum not only refers to using the technology for in vivo and ex vivo therapeutic applications. It also encompasses our mission to create a toolbox of technology enablers and solutions — from various gene editing and delivery modalities to development capabilities.

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The Beginning of Something Big
The Beginning of Something Big

With Intellia’s February 28 announcement, highlighting the latest data from our Phase 1 clinical trial of NTLA-2001 for the treatment of ATTR amyloidosis, we are seeing CRISPR’s potential as a one-time treatment for genetic diseases. Fifteen individuals with their own unique lives and stories are participating in Part 1 of our first-in-human Phase 1 study. And initial clinical test results suggest that relevant aspects of their disease have been significantly impacted.

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The Difference a Year Makes
The Difference a Year Makes

A year ago, when we laid out Intellia’s strategic priorities for 2021, we announced our goal of evaluating the initial clinical profile of NTLA-2001, the first-ever systemically delivered CRISPR therapy dosed in a patient. Even though the interim clinical data announcement happened in June last year, I’m still struck by how much it changed everything – not just for Intellia, but for the field of genome editing and even the trajectory of medicine.

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Opening a New Era of Medicine
Opening a New Era of Medicine

This week, we entered a new era of medicine. Intellia Therapeutics, the company I lead, announced the first clinical data in history suggesting that we can harness the genome editing technology CRISPR to precisely edit target cells within the body to treat — and potentially cure — a genetic disease.

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Farewell to Sickle Cell Disease in the Developing World
Farewell to Sickle Cell Disease in the Developing World

The year was 2000, and I was part of an advance crew scouring different parts of Africa in search of regions where we could – realistically – make Abbott’s HIV treatments readily available. I will never forget how village elders were left to care for their grandchildren. These kids’ parents, a whole generation of middle-aged adults, had died from HIV/AIDS.

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